2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-140494
    Biotin-PEG36-acid
    Biotin-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Biotin-PEG36-acid
  • HY-140586
    N-Benzyl-N-bis-PEG2 119580-47-1 98.0%
    N-Benzyl-N-bis-PEG2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-Benzyl-N-bis-PEG2
  • HY-132100
    Thiol-PEG2-t-butyl ester 1398044-50-2
    Thiol-PEG2-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Thiol-PEG2-t-butyl ester
  • HY-W042654
    BnO-PEG6-OH 24342-68-5 99.88%
    BnO-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). BnO-PEG6-OH is also a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    BnO-PEG6-OH
  • HY-W093833
    Benzyl-PEG9-alcohol 868594-48-3
    Benzyl-PEG9-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG9-alcohol
  • HY-169991
    1-(3,3-Difluoro-4-piperidinyl)piperazine 2168258-10-2
    1-(3,3-Difluoro-4-piperidinyl)piperazine is the PROTAC linker of CFT8634 (HY-145925B) and can be used in the synthesis of PROTACs.
    1-(3,3-Difluoro-4-piperidinyl)piperazine
  • HY-132027
    Benzyl-PEG7-acid
    Benzyl-PEG7-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG7-acid
  • HY-168450
    trans-Cyclohexane-p-bis(C-OTs) 134424-54-7
    trans-Cyclohexane-p-bis(C-OTs) is the linker that can be used for synthesis of PROTAC degrader dBAZ2 (HY-168448).
    trans-Cyclohexane-p-bis(C-OTs)
  • HY-140872
    N-(Boc-PEG2)-N-bis(PEG3-azide) 2353409-46-6
    N-(Boc-PEG2)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Boc-PEG2)-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(Boc-PEG2)-N-bis(PEG3-azide)
  • HY-140085
    N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) 2100306-49-6
    N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    N-(PEG2-C2-acid)-N-bis(PEG2-propargyl)
  • HY-132061
    Azido-PEG14-t-butyl ester
    Azido-PEG14-t-butyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG14-t-butyl ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG14-t-butyl ester
  • HY-140628
    Ald-Ph-PEG2-Boc 2100306-65-6
    Ald-Ph-PEG2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Ald-Ph-PEG2-Boc
  • HY-132102
    Bis-CH2-PEG2-acid 2250056-38-1
    Bis-CH2-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Bis-CH2-PEG2-acid
  • HY-175458
    Boc-piperidine-oxopiperidin 3078378-93-2
    Boc-piperidine-oxopiperidin is a PROTAC linker. Boc-piperidine-oxopiperidin can be used to synthesize PROTAC LYA914 (HY-175455).
    Boc-piperidine-oxopiperidin
  • HY-140191
    Amino-PEG4-(CH2)3CO2H 144598-03-8
    Amino-PEG4-(CH2)3CO2H is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Amino-PEG4-(CH2)3CO2H
  • HY-138716
    m-PEG9-azide 1354521-95-1
    m-PEG9-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG9-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG9-azide
  • HY-140277
    DBCO-PEG2-PFP ester 2304558-23-2
    DBCO-PEG2-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG2-PFP ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-PEG2-PFP ester
  • HY-W092895
    Cyclohexane-PEG1-Br 131665-94-6
    Cyclohexane-PEG1-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Cyclohexane-PEG1-Br
  • HY-134713
    Tos-PEG14-OH
    Tos-PEG14-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Tos-PEG14-OH
  • HY-140164
    Azido-PEG2-C2-sulfonic acid 1817735-39-9
    Azido-PEG2-C2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C2-sulfonic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG2-C2-sulfonic acid
PROTAC Linkers Isoform Comparison

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